Increased pulmonary vascular resistance secondary to vascular obstruction, neurohumoral mediators, cytokines, and reflex vasoconstriction another name for lasix Pulmonary vascular tone and diffusing capacity are affected by hormone levels and vary throughout the menstrual cycle a finding also noted in asthma, where air flow varies according to the phase of the cycle 39, 40, 88, and it is plausible that cyclic decreases in E2 levels promote vasoconstriction and vascular remodeling in otherwise predisposed individuals