The R320H in TRОІ has a reduced ligand binding affinity and a decreased T 3 dependent release of NCoR, and it mediates a weaker transactivation, but these effects are of a lesser degree than those we observed with R276W doxycycline side effects after stopping Fasting insulin levels in subclinical hypothyroidism are higher than in controls, and the homeostasis model of assessment HOMA IR index suggests insulin resistance in one study but not in another 43, 44